The Pennine Acute Hospitals
NHS Trust Formulary
 
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8 Malignant disease and immunosuppression
08-02-03 Anti-lymphocyte monoclonal antibodies

Rituximab MabThera®
First Choice
Concentrate for intravenous infusion

Restricted Item Specialist use only
Link  MHRA Drug Safety Update, December 2013: Rituximab: Screen for hepatitis b virus before treatment
Link  NICE TA137: Lymphoma (follicular non-Hodgkins) - rituximab
Link  NICE TA174: Leukaemia (chronic lymphocytic, first line) - rituximab
Link  NICE TA193: Leukaemia (chronic lymphocytic, relapsed) - rituximab
Link  NICE TA226: Rituximab for the first-line maintenance treatment of follicular non-Hodgkin’s lymphoma
Link  NICE TA243:Rituximab for the first-line treatment of stage III-IV follicular lymphoma (January 2012)
Link  NICE TA308: Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis
Link  NICE TA65: Rituximab for aggressive non-Hodgkin’s lymphoma
 

Cytotoxic Drug  Red View adult BNF  View SPC online  View childrens BNF
Alemtuzumab MabCampath®
Formulary
Concentrate for intravenous infusion

Restricted Item Specialist use only

Patient access scheme may be available. Patient access and monitoring form available from pharmacy.
Link  NICE TA312: Alemtuzumab for treating relapsing-remitting multiple sclerosis
 

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Obinutuzumab Gazyvaro®
Formulary
Concentrate for intravenous infusion
Restricted Item Specialist use only; for previously untreated chronic lymphocytic leukaemia (CLL) in patients with comorbidities making them unsuitable for full-dose fludarabine-based therapy

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Ofatumumab Arzerra®
Formulary
Concentrate for intravenous infusion

Restricted Item Specialist use only; CDF criteria must be met & funding approval received.
Link  MHRA Drug Safety Update, August 2014: Ofatumumab: reminder of risk of serious and fatal infusion reactions
Link  MHRA Drug Safety Update, January 2014: Ofatumumab: Screen for hepatitis B virus before treatment
 

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