The Pennine Acute Hospitals
NHS Trust Formulary
 
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5 Infections
This chapter of the formulary is not an antibiotic prescribing guide and is not intended to guide treatment choice.

Please refer to the relevant Pennine Acute policies (e.g. the Antibiotic Policy for Adult Patients, or Antibiotic Guidelines for Paediatrics) when making treatment choices.
05-03-03-02 Chronic hepatitis C

Peginterferon Alfa
Formulary
Injection
Link  NICE TA106: Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C
Link  NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA300: Peginterferon alfa and ribavirin for treating chronic hepatitis C in children and young people
 

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Ribavirin Copegus®
Formulary
Tablets
Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
 

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Daclatasvir Daklinza®
Formulary
Tablets

Restricted Item  Requires MDT discussion with ID team
Link  MHRA Safety Alert: Risk of hepatitis B reactivation with interferon-free regimens
Link  MHRA Safety Alert: Risk of interaction with vitamin K antagonists
Link  MHRA Safety Alert: Risk of severe bradycardia or heart block when taken with amiodarone
 

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Dasabuvir Exviera®
Formulary
Tablets

Restricted Item Requires MDT discussion with ID team
Link  MHRA Safety Alert: Risk of hepatitis B reactivation with interferon-free regimens
Link  MHRA Safety Alert: Risk of interaction with vitamin K antagonists
 

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Elbasvir/Grazoprevir Zepatier® 50mg/100mg
Formulary
Tablets

Restricted Item Requires MDT discussion with ID team
Link  NICE TA413: Elbasvir–grazoprevir for treating chronic hepatitis C
 

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Ledipasvir/Sofosbuvir Harvoni® 90mg/400mg
Formulary
Tablets

Restricted Item  Requires MDT discussion with ID team
Link  MHRA Safety Alert: Risk of hepatitis B reactivation with interferon-free regimens
Link  MHRA Safety Alert: Risk of interaction with vitamin K antagonists
Link  MHRA Safety Alert: Risk of severe bradycardia or heart block when taken with amiodarone
 

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Ombitasvir/Paritaprevir/Ritonavir Viekirax® 12.5mg/75mg/50mg
Formulary
Tablets

Restricted Item  Requires MDT discussion with ID team
Link  MHRA Safety Alert: interaction with levothyroxine
Link  MHRA Safety Alert: Risk of hepatitis B reactivation with interferon-free regimens
Link  MHRA Safety Alert: Risk of interaction with vitamin K antagonists
Link  MHRA Safety Alert: Ritonavir coadministration with a corticosteroid
 

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Sofosbuvir Sovaldi®
Formulary
Tablets
Restricted Item  Requires MDT discussion with ID team
Link  MHRA Safety Alert: Risk of hepatitis B reactivation with interferon-free regimens
Link  MHRA Safety Alert: Risk of interaction with vitamin K antagonists
Link  MHRA Safety Alert: Risk of severe bradycardia or heart block when taken with amiodarone
Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
 

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Sofosbuvir / Velpatasvir Epclusa®
Formulary
Tablets
Restricted Item  Requires MDT discussion with ID team
Link  NICE TA430: Sofosbuvir–velpatasvir for treating chronic hepatitis C
 

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Sofosbuvir / Velpatasvir / Voxilaprevir Vosevi®
Formulary
Tablets

Restricted Item  Requires MDT discussion with ID team
Link  NICE TA507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
 

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Simeprevir Olysio®
Formulary

Requires MDT discussion with ID team


For resistant cases only

Link  MHRA Safety Alert: Risk of severe bradycardia or heart block when taken with amiodarone
Link  NICE TA331: Simeprevir in combination with peginterferon alfa and ribavirin for treating genotypes 1 and 4 chronic hepatitis C
 

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Boceprevir Victrelis®
Non Formulary
Link  NICE TA253: Boceprevir for the treatment of genotype 1 chronic hepatitis C
 

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Ribavirin Rebetol®
Non Formulary

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Ribavirin Virazole®
Non Formulary

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Telaprevir Incivo®
Non Formulary
Link  NICE TA252:Telaprevir for the treatment of genotype 1 chronic hepatitis C
 

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