The Pennine Acute Hospitals
NHS Trust Formulary
 
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2 Cardiovascular system
02-10-02 Fibrinolytic drugs

Alteplase Actilyse®
Formulary
Actilyse Injection

Restricted ItemActilyse Cathflo 2mg (for thrombolytic treatment of occluded central venous access devices)is restricted to  NMGH Renal Unit only;

Approved for pulmonary embolism, acute ischaemic stroke (FGH only) and thrombolysis in acute limb ischaemia.

Alteplase is recommended for the treatment of acute ischaemic stroke in adults in accordance with its licensed indication if:
  • treatment is started as early as possible within 4.5 hoursof onset of stroke symptoms, AND
  • intracranial haemorrhage has been excluded by appropriate imaging techniques
  • See NICE TA264
    Link  Adult Loading Doses Policy
    Link  NICE TA264: Ischaemic stroke (acute) - alteplase
     

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    Streptokinase
    Formulary
    Injection

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    Tenecteplase Metalyse®
    Formulary
    Injection

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    Urokinase
    Formulary
    Injection

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    Reteplase Rapilysin®
    Non Formulary

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