The Pennine Acute Hospitals
NHS Trust Formulary
 
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2 Cardiovascular system
02-06-03 Other antianginal drugs

Ivabradine
Formulary
Tablets


Restricted Item Specialist initiation

Ivabradine should only be initiated in people with NYHA class II to IV stable chronic heart failure with systolic dysfunction who:
  • are in sinus rhythm with a heart rate of 75 bpm or more
  • have a left ventricular ejection fraction of 35% or less, AND
  • who have been stable for 4 weeks on optimised standard therapy with ACE inhibitors, beta-blockers and aldosterone antagonists (or when beta-blockers are contra-indicated or not tolerated).
  • Link  NICE TA 267: Ivabradine
     

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    Ranolazine Ranexa®
    Formulary
    Tablets

    Restricted Item Restricted to cardiac services (PAHT)

    For stable angina where patients are unsuitable for physical therapy or first and second line agents (PAHT).

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    Nicorandil Ikorel®
    Formulary
    Tablets

    Indicated for stable angina only in patients whose angina is inadequately controlled by first-line anti-anginal therapies, or who have a contra-indication or intolerance to first-line therapies, such as beta-blockers and/or calcium channel blockers.
    Link  MHRA Safety Alert: Risk of ulcer complications
     

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